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Evidence for Anti-Inflammatory Effects of Exercise in CKD

2014Journal article Open access
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dc.contributor.authorViana, João L.
dc.contributor.authorKosmadakis, George C.
dc.contributor.authorWatson, Emma L.
dc.contributor.authorBevington, Alan
dc.contributor.authorFeehally, John
dc.contributor.authorBishop, Nicolette C.
dc.contributor.authorSmith, Alice C.
dc.date.accessioned2021-04-28T14:38:38Z
dc.date.available2021-04-28T14:38:38Z
dc.date.issued2014
dc.description.abstractCKD is associated with a complex state of immune dysfunction characterized by immune depression, predisposing patients to infections, and immune activation, resulting in inflammation that associates with higher risk of cardiovascular disease. Physical exercise may enhance immune function and exert anti-inflammatory effects, but such effects are unclear in CKD. We investigated the separate effects of acute and regular moderate-intensity aerobic exercise on neutrophil degranulation (elastase release), activation of T lymphocytes (CD69 expression) and monocytes (CD86 and HLA-DR expression), and plasma inflammatory markers (IL-6, IL-10, soluble TNF-receptors, and C-reactive protein) in patients with predialysis CKD. A single 30-minute (acute) bout of walking induced a normal pattern of leukocyte mobilization and had no effect on T-lymphocyte and monocyte activation but improved neutrophil responsiveness to a bacterial challenge in the postexercise period. Furthermore, acute exercise induced a systemic anti-inflammatory environment, evidenced by a marked increase in plasma IL-10 levels (peaked at 1 hour postexercise), that was most likely mediated by increased plasma IL-6 levels (peaked immediately postexercise). Six months of regular walking exercise (30 min/d for 5 times/wk) exerted anti-inflammatory effects (reduction in the ratio of plasma IL-6 to IL-10 levels) and a downregulation of T-lymphocyte and monocyte activation, but it had no effect on circulating immune cell numbers or neutrophil degranulation responses. Renal function, proteinuria, and BP were also unaffected. These findings provide compelling evidence that walking exercise is safe with regard to immune and inflammatory responses and has the potential to be an effective anti-inflammatory therapy in predialysis CKD.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1681/ASN.2013070702pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.24/1769
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectAgedpt_PT
dc.subjectC-Reactive Proteinpt_PT
dc.subjectExercisept_PT
dc.subjectExercise Therapypt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectInflammationpt_PT
dc.subjectInflammation Mediatorspt_PT
dc.subjectInterleukin-10pt_PT
dc.subjectInterleukin-6pt_PT
dc.subjectLymphocyte Activationpt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectMonocytespt_PT
dc.subjectNeutrophil Activationpt_PT
dc.subjectReceptors, Tumor Necrosis Factor, Type Ipt_PT
dc.subjectReceptors, Tumor Necrosis Factor, Type IIpt_PT
dc.subjectRenal Insufficiency, Chronicpt_PT
dc.subjectT-Lymphocytespt_PT
dc.subjectWalkingpt_PT
dc.titleEvidence for Anti-Inflammatory Effects of Exercise in CKDpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2130pt_PT
oaire.citation.issue9pt_PT
oaire.citation.startPage2121pt_PT
oaire.citation.titleJournal of the American Society of Nephrologypt_PT
oaire.citation.volume25pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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