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Response of bone mineral density, inflammatory cytokines, and biochemical bone markers to a 32-week combined loading exercise programme in older men and women

2013Journal article Open access
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dc.contributor.authorMarques, Elisa A.
dc.contributor.authorMota, Jorge
dc.contributor.authorViana, João L.
dc.contributor.authorTuna, Diana
dc.contributor.authorFigueiredo, Pedro
dc.contributor.authorGuimarães, João T.
dc.contributor.authorCarvalho, Joana
dc.date.accessioned2021-04-28T14:58:48Z
dc.date.available2021-04-28T14:58:48Z
dc.date.issued2013
dc.description.abstractThis study examines the effects of 32 weeks of exercise training on balance, lower-extremity muscle strength, bone mineral density (BMD) and serum levels of bone metabolism and inflammatory markers in older adults. Forty-seven healthy older adults (women=24, men=23; mean age 68.2 years) participated in a exercise intervention (60min/session) that included resistance exercise training (2 days/week) at 75-80% of maximum plus a multicomponent weight-bearing impact exercise training (1 day/week). Outcome measures included lumbar spine and proximal femoral BMD, dynamic balance, muscle strength, serum levels of bone metabolism markers [osteocalcin (OC), C-terminal telopeptide of Type I collagen (CTX), osteoprotegerin (OPG) and receptor activator of nuclear factor kappa B ligand (RANKL)] and serum levels of inflammatory markers [high sensitive (hs)-C-reactive protein (CRP), interleukin (IL)-6, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ]. Potential confounding variables included body composition, dietary intake (using 4-day diet records), and accelerometer-based physical activity. After 32 weeks, both men and women increased dynamic balance (6.4%), muscle strength (11.0%) and trochanter (0.7%), intertrochanter (0.7%), total hip (0.6%), and lumbar spine BMD (1.7%), while OC, CTX, OPG and RANKL levels remained unchanged. In addition, hs-CRP and IFN-γ levels were decreased, while TNF-α levels were unchanged, and a decrease in IL-6 levels was only observed in men. These findings suggest that our combined impact protocol reduces inflammation and increases BMD, balance, and lower-extremity muscle strength, despite having little effect on bone metabolism markers. This reinforces the role of exercise to counteract the age-related inflammation, and the muscle strength, balance and BMD reduction.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.archger.2013.03.014pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.24/1778
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectAgedpt_PT
dc.subjectAged, 80 and overpt_PT
dc.subjectBiomarkerspt_PT
dc.subjectBone Densitypt_PT
dc.subjectBone and Bonespt_PT
dc.subjectC-Reactive Proteinpt_PT
dc.subjectCollagen Type Ipt_PT
dc.subjectCytokinespt_PT
dc.subjectExercisept_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectInterferon-gammapt_PT
dc.subjectInterleukin-6pt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectMuscle Strengthpt_PT
dc.subjectOsteocalcinpt_PT
dc.subjectOsteoprotegerinpt_PT
dc.subjectPeptidespt_PT
dc.subjectPostural Balancept_PT
dc.subjectRANK Ligandpt_PT
dc.subjectTumor Necrosis Factor-alphapt_PT
dc.titleResponse of bone mineral density, inflammatory cytokines, and biochemical bone markers to a 32-week combined loading exercise programme in older men and womenpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage233pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage226pt_PT
oaire.citation.titleArchives of Gerontology and Geriatricspt_PT
oaire.citation.volume57pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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