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GNAS A-1121G Variant is Associated with Improved Diastolic Dysfunction in Response to Exercise Training in Heart Failure Patients

2012Journal article Open access
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dc.contributor.authorAlves, A.
dc.contributor.authorGoldhammer, E.
dc.contributor.authorRibeiro, F.
dc.contributor.authorEynon, N.
dc.contributor.authorBen-Zaken Cohen, S.
dc.contributor.authorDuarte, J.
dc.contributor.authorViana, J.
dc.contributor.authorSagiv, M.
dc.contributor.authorOliveira, J.
dc.date.accessioned2021-04-28T15:00:21Z
dc.date.available2021-04-28T15:00:21Z
dc.date.issued2012
dc.description.abstractβ1-adrenergic receptors (ADRB1) and Gαs proteins (GNAS) play important roles in the regulation of cardiac function. The present study sought to investigate whether ADRB1 Arg389Gly (rs1801253), GNAS -1211 G/A (rs6123837) and GNAS 2291 C/T (rs6026584) variants are associated with left ventricular function and exercise tolerance in heart failure patients. 61 heart failure patients completed a 6-month exercise-training programme. Left ventricular ejection fraction (LVEF), mitral inflow velocities (deceleration time, and E/A ratio) and exercise tolerance (METs) were assessed at baseline and following exercise training. There were no associations between the studied variants and LVEF or E/A ratio measured at baseline and after exercise training. Deceleration time of early mitral flow was higher at baseline in GNAS -1211G allele carriers compared with -1211A allele homozygotes (P<0.05). Exercise training attenuated deceleration time in -1211G allele carriers (P<0.05) but not in -1211A allele homozygotes. Moreover, ADRB1 389Gly homozygotes had a greater training-induced increase in exercise tolerance than 389Arg homozygotes (P=0.04). This study shows that the functional GNAS -1121 G/A polymorphism is associated with diastolic function at baseline and in response to exercise training in heart failure patients. Furthermore, our data suggest that ADRB1 Arg389Gly polymorphism may influence exercise tolerance.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1055/s-0032-1316365pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.24/1779
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectAgedpt_PT
dc.subjectAnalysis of Variancept_PT
dc.subjectChromograninspt_PT
dc.subjectExercise Testpt_PT
dc.subjectExercise Tolerancept_PT
dc.subjectFemalept_PT
dc.subjectFollow-Up Studiespt_PT
dc.subjectGTP-Binding Protein alpha Subunits, Gspt_PT
dc.subjectGenetic Markerspt_PT
dc.subjectGenotyping Techniquespt_PT
dc.subjectHeart Failurept_PT
dc.subjectHomozygotept_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectReceptors, Adrenergic, beta-1pt_PT
dc.subjectTreatment Outcomept_PT
dc.subjectUltrasonographypt_PT
dc.subjectVentricular Function, Leftpt_PT
dc.subjectExercise Therapypt_PT
dc.subjectPolymorphism, Single Nucleotidept_PT
dc.titleGNAS A-1121G Variant is Associated with Improved Diastolic Dysfunction in Response to Exercise Training in Heart Failure Patientspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage280pt_PT
oaire.citation.issue03pt_PT
oaire.citation.startPage274pt_PT
oaire.citation.titleInternational Journal of Sports Medicinept_PT
oaire.citation.volume34pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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