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Twelve-week combined resistance and aerobic training confers greater benefits than aerobic training alone in nondialysis CKD

2018Journal article Open access
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dc.contributor.authorWatson, Emma L.
dc.contributor.authorGould, Douglas W.
dc.contributor.authorWilkinson, Thomas J.
dc.contributor.authorXenophontos, Soteris
dc.contributor.authorClarke, Amy L.
dc.contributor.authorVogt, Barbara Perez
dc.contributor.authorViana, João L.
dc.contributor.authorSmith, Alice C.
dc.date.accessioned2021-04-28T14:31:46Z
dc.date.available2021-04-28T14:31:46Z
dc.date.issued2018
dc.description.abstractThere is a growing consensus that patients with chronic kidney disease (CKD) should engage in regular exercise, but there is a lack of formal guidelines. In this report, we determined whether combined aerobic and resistance exercise would elicit superior physiological gains, in particular muscular strength, compared with aerobic training alone in nondialysis CKD. Nondialysis patients with CKD stages 3b-5 were randomly allocated to aerobic exercise {AE, n = 21; 9 men; median age 63 [interquartile range (IQR) 58-71] yr; median estimated glomerular filtration rate (eGFR) 24 (IQR 20-30) ml·min-1·1.73 m-2} or combined exercise [CE, n = 20, 9 men, median age 63 (IQR 51-69) yr, median eGFR 27 (IQR 22-32) ml·min-1·1.73 m-2], preceded by a 6-wk run-in control period. Patients then underwent 12 wk of supervised AE (treadmill, rowing, or cycling exercise) or CE training (as AE plus leg extension and leg press exercise) performed three times per week. Outcome assessments of knee extensor muscle strength, quadriceps muscle volume, exercise capacity, and central hemodynamics were performed at baseline, following the 6-wk control period, and at the end of the intervention. AE and CE resulted in significant increases in knee extensor strength of 16 ± 19% (mean ± SD; P = 0.001) and 48 ± 37% ( P < 0.001), respectively, which were greater after CE ( P = 0.02). AE and CE resulted in 5 ± 7% ( P = 0.04) and 9 ± 7% ( P < 0.001) increases in quadriceps volume, respectively ( P < 0.001), which were greater after CE ( P = 0.01). Both AE and CE increased distance walked in the incremental shuttle walk test [28 ± 44 m ( P = 0.01) and 32 ± 45 m ( P = 0.01), respectively]. In nondialysis CKD, the addition of resistance exercise to aerobic exercise confers greater increases in muscle mass and strength than aerobic exercise alone.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1152/ajprenal.00012.2018pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.24/1765
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectAgedpt_PT
dc.subjectCardiorespiratory Fitnesspt_PT
dc.subjectEnglandpt_PT
dc.subjectExercise Testpt_PT
dc.subjectExercise Therapypt_PT
dc.subjectExercise Tolerancept_PT
dc.subjectFemalept_PT
dc.subjectGlomerular Filtration Ratept_PT
dc.subjectHealth Statuspt_PT
dc.subjectHumanspt_PT
dc.subjectKidneypt_PT
dc.subjectMagnetic Resonance Imagingpt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectQuadriceps Musclept_PT
dc.subjectRenal Insufficiency, Chronicpt_PT
dc.subjectSeverity of Illness Indexpt_PT
dc.subjectTime Factorspt_PT
dc.subjectTreatment Outcomept_PT
dc.subjectMuscle Strengthpt_PT
dc.subjectResistance Trainingpt_PT
dc.titleTwelve-week combined resistance and aerobic training confers greater benefits than aerobic training alone in nondialysis CKDpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPageF1196pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPageF1188pt_PT
oaire.citation.titleAmerican Journal of Physiology-Renal Physiologypt_PT
oaire.citation.volume314pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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